Recent research has identified several natural compounds that could serve as potential antiviral inhibitors against the monkeypox virus, a disease that has resurfaced as a public health concern. The study, led by Mohamed Chebaibi from the Ministry of Health and Social Protection in Morocco, utilized advanced computational techniques to assess the efficacy of these compounds against a critical protein of the monkeypox virus known as A42R Profilin-like Protein.
The research highlights four specific compounds: Salsoline derivatives, Genistein, a semisynthetic derivative of kojic acid, and Naringenin. These compounds were subjected to molecular docking and analysis, revealing stronger binding affinities to the target protein than the FDA-approved antiviral drug, Tecovirimat. The binding affinities for the natural compounds ranged from -8.9 to -10 kcal/mol, compared to Tecovirimat’s -33.855 kJ/mol. Notably, the Salsoline derivative exhibited the most robust interaction with the protein’s binding pockets, suggesting its potential as a leading candidate for further development.
Chebaibi emphasized the significance of these findings, stating, “Our results suggest that these natural compounds not only have strong binding capabilities but also show promise as antiviral agents against monkeypox.” The study’s molecular dynamics simulations further confirmed the stability of these compounds when interacting with the viral protein, adding credibility to their potential effectiveness.
In terms of commercial implications, this research opens up new avenues for pharmaceutical companies looking to develop treatments for monkeypox and possibly other viral infections. The use of natural compounds could lead to more cost-effective and accessible antiviral therapies, addressing both efficacy and affordability concerns that have been prevalent with existing treatments.
Additionally, the growing interest in natural products for drug development could spur investment in biotechnology and pharmaceutical sectors focused on harnessing these compounds. As the world grapples with the resurgence of diseases like monkeypox, the pursuit of innovative and sustainable treatment options becomes increasingly relevant.
This study was published in ‘Frontiers in Chemistry,’ highlighting the ongoing efforts in the scientific community to find effective solutions to pressing health challenges.
